PROMOGRAN® Protease Modulating Matrix Dressing

SKU: 343M772028

Status: In Stock

CA$212.39

 

Description

PROMOGRAN™ Protease Modulating Matrix is comprised of a sterile, freeze-dried composite of 45% oxidized regenerated cellulose (ORC) and 55% collagen.

Optimum Wound Environment

PROMOGRAN™ Matrix maintains an optimal wound healing environment. This environment is conducive to granulation tissue formation, epithelization and rapid wound healing.

Maintains an optimum wound healing environment

In the presence of exudate, PROMOGRAN™  Matrix transforms into a soft, conformable, biodegradable gel. This allows contact with all areas of the wound.

Economic Value

An additional retrospective study analyzing cost-effectiveness in the management of neuropathic DFU (n=40), showed that wound Management with PROMOGRAN™  Matrix was more cost-effective per patient over 6 weeks of treatment as compared to standard care (Control).3

Product Description

PROMOGRAN™ Matrix is a topically applied interactive wound therapy. The product is a sterile, freeze dried composite of oxidised regenerated cellulose (ORC) and collagen. In the presence of exudate the PROMOGRAN™ Matrix transforms into a soft conformable, biodegradabile gel; this allows contact with all areas of the wound. Saline or Ringer's solution should be used to rehydrate PROMOGRAN™ Matrix on dry wounds.

PROMOGRAN™ Matrix modulates and re-balances the wound environment by the unique combination of:

  • Binding and inactivation of proteases (i.e. matrix metallo proteases, elastase and plasmin) which have been shown to be detrimental in excess chronic wounds
  • Binding and protection of naturally occurring growth factors against degradation by these excecess proteases.

The naturally occurring, protected growth factors are released back into the wound, while the detrimental proteases remain upon bio-degradation of the PROMOGRAN™ Matrix. PROMOGRAN™ Matrix has demonstrated free radical scavenging properties.

Indications for use

PROMOGRAN™ Matrix is intended for the management of all wounds healing by secondary intent which are clear of necrotic tissue, including:

  • Diabetic ulcers
  • Venous ulcers
  • Pressure ulcers
  • Ulcers caused by mixed vascular aetiologies
  • Traumatic and surgical wounds
  • PROMOGRAN™ Matrix can be used under compression therapy

 

More Info

More Info

References

1. Wollina, U. et al. Some Effects of a Topical Collagen-Based Matrix on the Microcirculation and Wound Healing in Patients with Chronic Venous Leg Ulcers: Preliminary Observations. Low Extr WOUNDS 2005, vol 4(4):214-224.

2. Nisi G. et al. Use of a protease-modulating mat ix in the treatment of pressure sores. Chir Ital 2005, vol. 57(4):465-468.

3. Lazaro-Martinez, J. L. et al. Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers. F.R. Circ. Esp. 2007, 82(1),27-31.

4. Veves, A. et al. A Randomized, Controlled Trial of Promogran (a Collagen Oxidized Regenerated Cellulose Dressing) vs Standard Treatment in the Management of Diabetic Foot Ulcers. Arch. Surg 2002, vol. 137:822-827.

5. Vin, F. et al. The healing properties of Promogran in venous leg ulcers. J. Wound Care 2002; 11(9):335-41. 

6. Lobmann, R. et al. Expression of matrix metalloproteinases and growth factors in diabetic foot wounds treated with a protease absorbent dressing. J Diabetes Complications 2006; 20(5): 329-335.

7. Ulrich, D. et al. Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with diabetic foot ulcers. J Wound Ostomy Continence Nurs. 2011 38(5) 1-7.

8. Smeets, R. et al. Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. Int. Wound J. 2008, 5:195-203.

9. Kakagia, D.D. et al. Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial. J Diabetes Complications 2007; 21(6): 387-91.

10. Kloeters, O, Unglaub F, de Laat E, van Abeelen M, Ulrich D. Prospective and randomized evaluation of the protease-modulating effect of oxidised regenerated cellulose/collagen matrix treatment in pressure sore ulcers. Int Wound J. 2015;13(6):1231-6.

11. Lobmann R, Zemlin C, Motzkau M, Reschke K,Lehnert H. Expression of matrix metalloproteinases and growth factors in diabetic foot wounds treated with a protease absorbent dressing. J Diabetes Complications. 2006;20(5):329-35.

12. Hart , J. et al. The role of oxidized regenerated cellulose / collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. Int J Biochem Cell Biol 2002;34:1557-1570. 

13. Lanzara S, Tacconi G, Gianesini S, et al. A pilot randomized trial to determine the effects of a new active dressing on wound healing of venous leg ulcers. Paper presented at: Conference of the European Wound Management Association; May 14-16, 2008; Lisbon, Portugal.

 

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